Article

Engineering patient-derived organotypic bone model to understand osteoanabolic therapy in skeletal disease

2025-04-22

Abstract excerpt

Bone-forming therapies often fail in genetic skeletal disorders, highlighting critical gaps in mechanistic understanding and therapy evaluation. We developed 3D bioprinted organotypic bone models using primary cells from a patient with FKBP10-mutant osteogenesis imperfecta (OI) and from metabolically healthy controls obtained via femoral osteotomy (FO). The platform combines cyclic mechanical loading and reseeding...

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Literature Corpus work: 629df96d-bd83-5526-85c7-7d876a6341e6
DOI: 10.1101/2025.04.17.649276

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