Article

Stereotypic Neutralizing V <sub>H</sub> Clonotypes Against SARS-CoV-2 RBD in COVID-19 Patients and the Healthy Population

2020-06-29

Abstract excerpt

In six of seven severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients, V H clonotypes, encoded by either immunoglobin heavy variable (IGHV)3-53 or IGHV3-66 and immunoglobin heavy joining (IGHJ)6, were identified in IgG 1 , IgA 1 , and IgA 2 subtypes, with minimal mutations, and could be paired with diverse light chains, resulting in binding to the SARS-CoV-2 receptor-binding domain (RBD). Becau...

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Literature Corpus work: 21e4f90b-7d7c-5698-9e2c-c35b4cdd74a1
DOI: 10.1101/2020.06.26.174557

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