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Article

Stereotypic neutralizing VH antibodies against SARS-CoV-2 spike protein receptor binding domain in patients with COVID-19 and healthy individuals.

Science translational medicine - 27 Jan 2021

Kim Sang Il, Noh Jinsung, Kim Sujeong, Choi Younggeun, Yoo Duck Kyun, Lee Yonghee, Lee Hyunho, Jung Jongtak, Kang Chang Kyung, Song Kyoung-Ho, Choe Pyoeng Gyun, Kim Hong Bin, Kim Eu Suk, Kim Nam-Joong, Seong Moon-Woo, Park Wan Beom, Oh Myoung-Don, Kwon Sunghoon, Chung Junho

Abstract excerpt

Stereotypic antibody clonotypes exist in healthy individuals and may provide protective immunity against viral infections by neutralization. We observed that 13 of 17 patients with COVID-19 had stereotypic variable heavy chain (VH) antibody clonotypes directed against the receptor binding domain (RBD) of SARS-CoV-2 spike protein. These antibody clonotypes were composed of immunoglobulin heavy variable 3-53...

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Share to Antibodies, Neutralizing
Share to Antibodies, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clone Cells

Share to Immunoglobulin G

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin Variable Region

Share to Protein Domains

Share to Spike Glycoprotein, Coronavirus

Source

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Identifiers

PMID: 33397677
DOI: 10.1126/scitranslmed.abd6990
PMCID: PMC7875332

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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