Article

5β-Dihydrotestosterone and mutant androgen receptor vulnerability in prostate cancer

2026-07-30

Abstract excerpt

<title>Abstract</title> <p>BACKGROUND Bipolar androgen therapy (BAT) exploits the paradoxical vulnerability of castration-resistant prostate cancer (CRPC) to supraphysiologic androgen. However, testosterone (T) is used clinically for BAT, which broadly activates wild-type androgen receptor (AR) in normal androgen-responsive tissues and can cause substantial systemic androgenic effects. 5β-Dihydrotestosterone (5β...

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Literature Corpus work: 21e4f3d1-91ae-570a-be05-1dc489c66f38
DOI: 10.21203/rs.3.rs-10462224/v1

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