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Article

Identification of truncated variants in GLI family zinc finger 3 (GLI3) associated with polydactyly.

Journal of orthopaedic surgery and research - 30 Jul 2024

Wang Run-Yan, Xiong Qin, Chang Si-Hua, Jin Jie-Yuan, Xiang Rong, Zeng Lei, Yu Fang

Abstract excerpt

BACKGROUND: Polydactyly is a prevalent congenital anomaly with an incidence of 2.14 per 1000 live births in China. GLI family zinc finger 3 (GLI3) is a classical causative gene of polydactyly, and serves as a pivotal transcription factor in the hedgehog signaling pathway, regulating the development of the anterior-posterior axis in limbs. METHODS: Three pedigrees of polydactyly patients were enrolled from Hunan...

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Exome Sequencing
Mutation
Nerve Tissue Proteins
Pedigree
Polydactyly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Zinc Finger Protein Gli3

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PMID: 39080720
DOI: 10.1186/s13018-024-04928-0
PMCID: PMC11287838

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Identification of truncated variants in GLI family zinc finger 3 (GLI3) associated with polydactyly.PMID 39080720Read ↗

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