Article

Repurposed endogenous virus-like vesicles mediate dendritic cell long-range antigen presentation and T cell activation for enhanced cancer vaccination

2025-11-26

Abstract excerpt

<h4>Summary</h4> Dendritic cells (DCs) release extracellular vesicles (DEVs) that amplify antigen presentation while incorporating patient-derived, rapidly evolving antigens. By enriching peptide-MHC and co-stimulatory ligands orders-of-magnitude above donor-cell levels, DEVs emerge as potent vesicle-vaccines, although efficacy remains limited by unclear mechanisms. We show that DCs repurpose viral components to...

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Literature Corpus work: 594ecd33-6fdc-525f-ab8b-5569f6c38c64
DOI: 10.1101/2025.11.23.690059

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