Article

Mineralocorticoid and glucocorticoid receptor interaction drives TGFβ1-induced triple-negative breast cancer progression to metastasis

2025-11-05

Abstract excerpt

In triple-negative breast cancer (TNBC), p38 MAPK phosphorylates the glucocorticoid receptor (GR) at N-terminal Ser134 in response to cytokines, such as TGFβ1. Phospho-Ser134-GR (pSer134-GR) regulates genes that promote migratory/invasive behavior and altered metabolism. In addition to acting as ligands for GR, glucocorticoids also activate closely-related mineralocorticoid receptors (MR). Elevated MR activity via...

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Literature Corpus work: 2151f38a-067d-58dd-8557-17410f9e0d33
DOI: 10.1101/2025.11.03.686330

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