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Article

Mineralocorticoid and glucocorticoid receptor cooperation drives advanced phenotypes in triple-negative breast cancer.

Endocrinology - 6 May 2026

Posani Sai Harshita, Diep Caroline H, Krutilina Raisa I, Playa Hilaire C, Seagroves Tiffany N, Blenis John, Lange Carol A

Abstract excerpt

Oncogenic cell signaling, including the activation of cellular stress or cytokine-induced pathways, is a hallmark of cancer. In triple-negative breast cancer (TNBC), p38 MAPK phosphorylates glucocorticoid receptors (GR) at Ser134 in response to cytokines such as TGFβ1. This activated Phospho-Ser134-GR (pSer134-GR) regulates genes promoting cancer cell migration, invasion, and altered metabolism. Glucocorticoids...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

Share to p38 Mitogen-Activated Protein Kinases

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Identifiers

PMID: 42080517
DOI: 10.1210/endocr/bqag055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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