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The impact of glucocorticoid receptor transactivation on context-dependent cell migration dynamics

4 Feb 2025

Abstract excerpt

The glucocorticoid receptor (GR) plays a significant role in breast cancer cell behaviour, although data on its effects are conflicting. The impact of GR agonist dexamethasone (dex) and antagonist mifepristone (mif) on oestrogen-positive (ER+) and triple-negative (TN) breast cancer cell lines in both 2D and 3D cultures was studied using multiple in vitro functional assays and transcriptome sequencing. GR...

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PMID: 39905197
DOI: 10.1038/s41598-025-88666-1

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