Article

Low GROa/CXCL1 expression predicts poor outcome and promotes tumour progression in vivo and in vitro, revealing a context-dependent tumour-suppressive role in triple-negative breast cancer

2026-07-02

Abstract excerpt

<title>Abstract</title> <p> Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype with limited treatment options. GROa/CXCL1 is a proinflammatory chemokine that presents high expression levels in TNBC, yet its precise role remains unclear. In this study, GROa/CXCL1 function was studied using TNBC (MDA-MB-231) and luminal (MCF-7) cell lines. GROa/CXCL1 silencing led to a significant in...

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Literature Corpus work: 7f697fb8-6dd9-5a3c-b4ee-7f2ee746f238
DOI: 10.21203/rs.3.rs-9982165/v1

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