Article

TMScal: A Clinical Decision Support Tool for Prognostic Stratification of Microsatellite-Stable Cancers

2026-08-24

Abstract excerpt

PURPOSE Microsatellite-stable (MSS) cancers comprise 70–85% of patients but lack prognostic biomarkers to guide clinical decision-making. Current metrics—tumor mutational burden (TMB), copy number variation (CNV), and microsatellite instability (MSI)—measure the quantity of genomic instability but discard sequence-context information that encodes repair pathway activity. We developed TMScal, a clinical decision su...

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Literature Corpus work: 2135b0a8-fc1c-5890-b201-403c2c29f5b9
DOI: 10.20944/preprints202608.1628.v1

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