Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New Insights into the Role of E2s in the Pathogenesis of Diseases: Lessons Learned from UBE2O.

31 Mar 2018

Abstract excerpt

Intracellular communication via ubiquitin (Ub) signaling impacts all aspects of cell biology and regulates pathways critical to human development and viability; therefore aberrations or defects in Ub signaling can contribute to the pathogenesis of human diseases. Ubiquitination consists of the addition of Ub to a substrate protein via coordinated action of E1-activating, E2-conjugating and E3-ligating enzymes....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Histone Deacetylase Inhibitors Research
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29562734
DOI: 10.14348/molcells.2018.0008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New Insights into the Role of E2s in the Pathogenesis of Diseases: Lessons Learned from UBE2O.PMID 29562734Read ↗

E2 enzymes: more than just middle menSemantic proximity Read ↗

The Molecular Basis of Ubiquitin-Conjugating Enzymes (E2s) as a Potential Target for Cancer TherapySemantic proximity Read ↗

Deubiquitinating enzymes in cellular signaling and disease regulationSemantic proximity Read ↗

Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinasesSemantic proximity Read ↗

Ubiquitin and Ubiquitin-like Proteins in Cancer, Neurodegenerative Disorders, and Heart DiseasesSemantic proximity Read ↗

Ubiquitin becomes ubiquitous in cancerSemantic proximity Read ↗

Deubiquitinases as novel therapeutic targets for diseasesSemantic proximity Read ↗

The ubiquitin system: pathogenesis of human diseases and drug targetingSemantic proximity Read ↗

Role of ubiquitin ligases and the proteasome in oncogenesis: novel targets for anticancer therapies.Semantic proximity Read ↗

Spotlights on ubiquitin-specific protease 12 (USP12) in diseases: from multifaceted roles to pathophysiological mechanismsSemantic proximity Read ↗

DUBs, the regulation of cell identity and diseaseSemantic proximity Read ↗

The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human PathologiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.