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Li Fraumeni syndrome in the UK: clinical characteristics and outcomes of TP53 carriers

21 Aug 2025

Abstract excerpt

BACKGROUND: Li Fraumeni syndrome (LFS), a rare genetic condition, poses a significant health impact due to the ∼75%-90% lifetime risk of developing cancer in affected individuals. Due to the rarity of this disease, little is known about the outcomes, clinical characteristics, and treatments of cancer for patients with LFS. PATIENTS AND METHODS: We present a retrospective dataset of 57 patients from 41 families...

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PMID: 40840234
DOI: 10.1016/j.esmoop.2025.105541

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