Article

A <i>Wars2</i> mutant mouse shows a sex and diet specific change in fat distribution, reduced food intake and depot-specific upregulation of WAT browning

2022-05-24

Abstract excerpt

1. <h4>Background</h4> Increased waist-to-hip ratio (WHR) is associated with increased mortality and risk of type 2 diabetes and cardiovascular disease. The TBX15 - WARS2 locus has consistently been associated with increased WHR. Previous study of the hypomorphic Wars2 V117L/V117L mouse model found phenotypes including severely reduced fat mass, and white adipose tissue (WAT) browning, suggesting Wars2 could...

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Literature Corpus work: 20e2c015-c197-518b-94fb-7f5d53ce252e
DOI: 10.1101/2022.05.23.493147

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