Article
GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI.
Science advances - 1 Sept 2019
Couto Alves Alexessander, De Silva N Maneka G, Karhunen Ville, Sovio Ulla, Das Shikta, Taal H Rob, Warrington Nicole M, Lewin Alexandra M, Kaakinen Marika, Cousminer Diana L, Thiering Elisabeth, Timpson Nicholas J, Bond Tom A, Lowry Estelle, Brown Christopher D, Estivill Xavier, Lindi Virpi, Bradfield Jonathan P, Geller Frank, Speed Doug, Coin Lachlan J M, Loh Marie, Barton Sheila J, Beilin Lawrence J, Bisgaard Hans, Bønnelykke Klaus, Alili Rohia, Hatoum Ida J, Schramm Katharina, Cartwright Rufus, Charles Marie-Aline, Salerno Vincenzo, Clément Karine, Claringbould Annique A J, van Duijn Cornelia M, Moltchanova Elena, Eriksson Johan G, Elks Cathy, Feenstra Bjarke, Flexeder Claudia, Franks Stephen, Frayling Timothy M, Freathy Rachel M, Elliott Paul, Widén Elisabeth, Hakonarson Hakon, Hattersley Andrew T, Rodriguez Alina, Banterle Marco, Heinrich Joachim, Heude Barbara, Holloway John W, Hofman Albert, Hyppönen Elina, Inskip Hazel, Kaplan Lee M, Hedman Asa K, Läärä Esa, Prokisch Holger, Grallert Harald, Lakka Timo A, Lawlor Debbie A, Melbye Mads, Ahluwalia Tarunveer S, Marinelli Marcella, Millwood Iona Y, Palmer Lyle J, Pennell Craig E, Perry John R, Ring Susan M, Savolainen Markku J, Rivadeneira Fernando, Standl Marie, Sunyer Jordi, Tiesler Carla M T, Uitterlinden Andre G, Schierding William, O'Sullivan Justin M, Prokopenko Inga, Herzig Karl-Heinz, Smith George Davey, O'Reilly Paul, Felix Janine F, Buxton Jessica L, Blakemore Alexandra I F, Ong Ken K, Jaddoe Vincent W V, Grant Struan F A, Sebert Sylvain, McCarthy Mark I, Järvelin Marjo-Riitta
Abstract excerpt
Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how...
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