Article

A developmentally-inspired hypoxia condition promotes kidney organoid differentiation from human pluripotent stem cells

2023-07-31

Abstract excerpt

<h4>ABSTRACT</h4> Kidney organoids derived from human pluripotent stem cells (hPSCs) lack a contiguous network of collecting ducts, which limits their utility in modeling kidney development and disease. Here, we report the generation of kidney organoids containing ureteric bud (UB)-derived collecting ducts connected to metanephric mesenchyme (MM)-derived nephrons using developmentally-inspired hypoxic differentia...

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Literature Corpus work: d23d9ee0-7ec6-5901-abd8-1fe2d8658b6c
DOI: 10.1101/2023.07.29.551084

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