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Article

Functional Genetic Targeting of Embryonic Kidney Progenitor Cells Ex Vivo

9 Sept 2014

Abstract excerpt

The embryonic mammalian metanephric mesenchyme (MM) is a unique tissue because it is competent to generate the nephrons in response to Wnt signaling. An ex vivo culture in which the MM is separated from the ureteric bud (UB), the natural inducer, can be used as a classic tubule induction model for studying nephrogenesis. However, technological restrictions currently prevent using this model to study the molecular...

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PMID: 25201883
DOI: 10.1681/asn.2013060584

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