Article

Comparative modeling of fetal exposure to maternal long-acting injectable versus oral daily antipsychotics

2024-10-23

Abstract excerpt

This study employed physiologically based pharmacokinetic (PBPK) modelling to compare the extent of fetal exposure between oral and long-acting injectable (LAI) aripiprazole and olanzapine. Adult and pregnancy PBPK models were developed and validated with relevant clinical data. Relevant indices of fetal exposure during pregnancy were predicted from concentration-time data at steady-state dosing for both oral and...

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Literature Corpus work: 20c66f53-1567-591f-9bd1-ebee53d4e706
DOI: 10.1101/2024.10.22.24315924

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