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Characterization of lamotrigine disposition changes during and after pregnancy in women with epilepsy

1 Jan 2025

Abstract excerpt

Abstract Background Lamotrigine clearance can change drastically in pregnant women with epilepsy (PWWE) making it difficult to assess the need for dosing adjustments. Our objective was to characterize lamotrigine pharmacokinetics in PWWE during pregnancy and postpartum along with a control group of nonpregnant women with epilepsy (NPWWE). Methods The Maternal Outcomes and Neurodevelopmental Effects of...

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PMID: 39764656
DOI: 10.1002/phar.4640

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