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Prediction of Maternal and Fetal Doravirine Exposure by Integrating Physiologically Based Pharmacokinetic Modeling and Human Placenta Perfusion Experiments

17 May 2022

Abstract excerpt

Doravirine is currently not recommended for pregnant women living with human immunodeficiency virus because efficacy and safety data are lacking. This study aimed to predict maternal and fetal doravirine exposure by integrating human placenta perfusion experiments with pregnancy physiologically based pharmacokinetic (PBPK) modeling. Ex vivo placenta perfusions were performed in a closed–closed configuration, in...

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PMID: 35579825
DOI: 10.1007/s40262-022-01127-0

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