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Article

Structural and mechanistic diversity in p53-mediated regulation of organismal longevity across taxonomical orders

2024-08-06

Abstract excerpt

The accumulation of senescent cells induces several aging phenotypes, and the p53 tumor suppressor protein regulates one of the two known cellular senescence pathways. p53’s regulation of senescence is however not clear. For example, p53 deficiency in some mice has been shown to rescue premature aging while others display significant aging phenotype when p53-deficient. This study seeks to elucidate, structurally a...

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Identifiers and source

Literature Corpus work
20a4e70a-9b7c-5749-86f0-79a750e9efc8
DOI
10.1101/2024.08.05.606567
Open publication

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Structural and mechanistic diversity in p53-mediated regulation of organismal longevity across taxonomical ordersDOI 10.1101/2024.08.05.606567
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