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Sirtuin Evolution at the Dawn of Animal Life

1 Sept 2022

Abstract excerpt

Sirtuins are a family of proteins that protect against cellular injury and aging; understanding their evolution should reveal fundamental mechanisms governing longevity. "Early-branching" animals such as sea sponges and jellyfish have been understudied in previous analyses of sirtuin diversity. These organisms not only hold important positions at the base of the evolutionary tree, but also have unique aging...

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PMID: 36065792
DOI: 10.1093/molbev/msac192

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