Article
Tuberculosis vaccine with high predicted population coverage and compatibility with modern diagnostics.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jan 2014
Knudsen Niels Peter H, Nørskov-Lauritsen Sara, Dolganov Gregory M, Schoolnik Gary K, Lindenstrøm Thomas, Andersen Peter, Agger Else Marie, Aagaard Claus
Abstract excerpt
A central goal in vaccine research is the identification of relevant antigens. The Mycobacterium tuberculosis chromosome encodes 23 early secretory antigenic target (ESAT-6) family members that mostly are localized as gene pairs. In proximity to five of the gene pairs are ESX secretion systems involved in the secretion of the ESAT-6 family proteins. Here, we performed a detailed and systematic investigation of...
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