Article

Evidence for reduced somatic T-cell receptor sequence diversity profiles among Midwestern Amish in an aging cohort study

2026-01-26

Abstract excerpt

Late-onset Alzheimer disease (LOAD), the most common form of dementia among older adults, is a neurodegenerative disease characterized by brain amyloid-β (Aβ) plaque deposition and neurofibrillary tangles. The causes of LOAD are not known but several recent lines of evidence implicate the adaptive immune system. Here, we sought to characterize somatic T-cell receptor (TCR) sequence diversity profiles and class I a...

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Literature Corpus work: 208a8916-321d-5fee-b124-c5ffd5731d27
DOI: 10.64898/2026.01.25.26344754

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Evidence for reduced somatic T-cell receptor sequence diversity profiles among Midwestern Amish in an aging cohort studyDOI 10.64898/2026.01.25.26344754Read

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