Article
An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 May 2005
Wikby Anders, Ferguson Frederick, Forsey Rosalyn, Thompson Julie, Strindhall Jan, Löfgren Sture, Nilsson Bengt-Olof, Ernerudh Jan, Pawelec Graham, Johansson Boo
Abstract excerpt
In the previous OCTO longitudinal study, we identified an immune risk phenotype (IRP) of high CD8 and low CD4 numbers and poor proliferative response. We also demonstrated that cognitive impairment constitutes a major predictor of nonsurvival. In the present NONA longitudinal study, we simultaneously examine in a model of allostatic load IRP and compromised cognition in 4-year survival in a population-based...
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