Article

Uncertainty-Aware Deep Learning for Multi-Metric and Dose-Specific Prediction of Drug Synergy

2025-11-07

Abstract excerpt

Accurately predicting drug synergy is critical to accelerate the development of combination therapies for cancer and other complex diseases. Yet, the vast combinatorial drug and dose space poses a substantial challenge, even for modern deep learning approaches. Existing approaches often lack generalisability, collapse rich dose–response surfaces into single dose-averaged synergy scores, and fail to quantify predic...

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Literature Corpus work: 205843bc-e282-5076-8bb7-4e160391abdf
DOI: 10.1101/2025.11.05.686895

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