Article

HSSynergy: Scale-Aware Hierarchical Attention for Interpretable Drug Synergy Prediction

2026-06-11

Abstract excerpt

<title>Abstract</title> <p>Combination therapy offers a promising strategy for cancer treatment by reducing toxicity and overcoming drug resistance. However, existing substructure-based prediction methods may struggle to effectively capture the scale-specific features of substructure interactions and often overlook cell-line-specific substructure selection, which can limit mechanistic interpretability. To address...

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Literature Corpus work: 14562d51-165e-509f-a487-2243148cc115
DOI: 10.21203/rs.3.rs-9715589/v1

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