Article

SynVerse: A Framework for Systematic Evaluation of Deep Learning Based Drug Synergy Prediction Models

2025-05-01

Abstract excerpt

Synergistic drug combinations are often used to treat cancer. Experimental exploration of all possibilities is expensive. Deep learning (DL) for predicting the synergy of drug pairs in specific cell lines might provide an alternative. However, current approaches often suffer from data leakage. They also lack systematic ablation studies. To address these gaps, we propose SynVerse, a comprehensive evaluation framewo...

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Literature Corpus work: 53d3e3c0-3c91-53d0-b13d-f354ba39023b
DOI: 10.1101/2025.04.30.651516

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