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MiR-27b-3p Targeting BDNF Inhibits TrkB / CREB Signaling Pathway and Improves IL-1 β Induced Chondrocytic Inflammation

2021-02-26

Abstract excerpt

Knee Osteoarthritis (KOA) is a chronic disease characterized by progressive disability and joint pain. Meniscus chondrocytes apoptosis is the main cause of reduced chondrocyte number and self-repair function. The purpose of this study was to investigate the role of miR-27b-3p in KOA.In this study, we found that the expression of miR-27b-3p was downregulated in cultured IL-1β treated chondrocyte and cartilage...

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Literature Corpus work: 204a6035-1902-5950-8e0f-e1888f1f0dac
DOI: 10.20944/preprints202102.0602.v1

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