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Article

miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4

16 Apr 2012

Abstract excerpt

INTRODUCTION: miR-146a is one of the first identified miRNAs expressed differentially in osteoarthritis (OA) cartilage. However, the role it plays in OA pathogenesis is not clear. The aim of this study is to identify a molecular target of miR-146a, thereby elucidating its function in chondrocytes during OA pathogenesis. METHODS: Primary chondrocytes from Sprague-Dawley rats were treated with IL-1β before the...

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PMID: 22507670
DOI: 10.1186/ar3798

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