Article

Resveratrol protects against IL-1β-induced chondrocyte damage via the SIRT1/FOXO1 signalling pathway

2022-05-18

Abstract excerpt

<h4>Purpose: </h4> Osteoarthritis (OA) is a common joint disease characterized by cartilage degeneration, synovial inflammation, osteophytes, and subchondral osteosclerosis. The present study aimed to investigate the effects of RES on in the extracellular matrix ，autophagy and apoptosis in the process of osteoarthritis via the SIRT1/FOXO1 pathway. <h4>Methods: </h4> The microenvironment of OA chondrocytes was simu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 20fc639c-fbd0-53f5-a218-f5eef1e711ae
DOI: 10.21203/rs.3.rs-1663807/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Resveratrol protects against IL-1β-induced chondrocyte damage via the SIRT1/FOXO1 signalling pathwayDOI 10.21203/rs.3.rs-1663807/v1Read

Quercetin activates autophagy suppresses apoptosis, inflammation and cartilage matrix degradation in LPS-induced chondrocytes through targeting AMPK/mTOR/ULK1 signaling pathwaySemantic proximity Read

Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressionsSemantic proximity Read

SIRT1 Inhibits the Catabolic Effect of IL-1βThrough TLR2/SIRT1/NF-κB Pathway in HumanDegenerative Nucleus Pulposus CellsSemantic proximity Read

SIRT1 regulation of apoptosis of human chondrocytesSemantic proximity Read

Unraveling the path to osteoarthritis management: targeting chondrocyte apoptosis for therapeutic interventionSemantic proximity Read

Identification of the Resveratrol Potential Targets in the Treatment of OsteoarthritisSemantic proximity Read

miR-200a/b relieves IL-1β-induced cell injury in knee articular chondrocytes ex-vivo by targeting fucosyltransferase 4 (FUT4)Semantic proximity Read

ADSCs increase the autophagy of chondrocytes through decreasing miR-7-5p in Osteoarthritis rats by targeting ATG4ASemantic proximity Read

Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting SIRT6Semantic proximity Read

Sirtuins in osteoarthritis: current understandingSemantic proximity Read

β-Sitosterol Preconditioning Enhances the Resistance of BMSCs and Chondrocyte to Oxidative Stress and Promotes Cartilage Repair in OsteoarthritisSemantic proximity Read

Beneficial effect of resveratrol on phenotypic features and activity of osteoarthritic osteoblasts.Semantic proximity Read