Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NF-κB inducible miR-30b-5p aggravates joint pain and loss of articular cartilage via targeting SIRT1-FoxO3a-mediated NLRP3 inflammasome

29 Aug 2021

Abstract excerpt

MicroRNAs (miRNAs) contribute to osteoarthritis (OA) development. Nevertheless, the function and mechanism of miR-30b-5p in OA are unclear. In the present article, we gauged the miR-30b-5p level in OA patients and analyzed its correlation with OA stages. Then, we conducted in-vivo and in-vitro gain-of-function assays to determine the function of miR-30b-5p, silent information regulator 2 homolog 1 (SIRT1) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Circular RNAs in diseases
Share to Osteoarthritis Treatment and Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34455406
DOI: 10.18632/aging.203466

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NF-κB inducible miR-30b-5p aggravates joint pain and loss of articular cartilage via targeting SIRT1-FoxO3a-mediated NLRP3 inflammasomePMID 34455406Read ↗

Long noncoding RNA LINC00461 induced osteoarthritis progression by inhibiting miR-30a-5pSemantic proximity Read ↗

MiR-4303 relieves chondrocyte inflammation by targeting ASPN in osteoarthritisSemantic proximity Read ↗

Positive Feedback Loop LINC00511/miR-150-5p/SP1 Modulates Chondrocyte Apoptosis and Proliferation in OsteoarthritisSemantic proximity Read ↗

Silencing miR-146a-5p Protects against Injury-Induced Osteoarthritis in MiceSemantic proximity Read ↗

The Role of MicroRNAs in the Pathophysiology of OsteoarthritisSemantic proximity Read ↗

Long non-coding RNA PCAT-1 regulates apoptosis of chondrocytes in osteoarthritis by sponging miR-27b-3pSemantic proximity Read ↗

PSMB9 Exacerbates Chondrocyte Injury in Osteoarthritis via Activation of the NF-κB PathwaySemantic proximity Read ↗

MiR-653-5p drives osteoarthritis pathogenesis by modulating chondrocyte senescenceSemantic proximity Read ↗

LINC01534 promotes the aberrant metabolic dysfunction and inflammation in IL-1β-simulated osteoarthritic chondrocytes by targeting miR-140-5pSemantic proximity Read ↗

CircRNA_0092516 regulates chondrocyte proliferation and apoptosis in osteoarthritis through the miR-337-3p/PTEN axisSemantic proximity Read ↗

The complex landscape of microRNAs in articular cartilage: biology, pathology, and therapeutic targetsSemantic proximity Read ↗

Role of MicroRNA, LncRNA, and Exosomes in the Progression of Osteoarthritis: A Review of Recent LiteratureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.