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Article

Untranslated regions (UTRs) are a potential novel source of neoantigens for personalised immunotherapy.

Frontiers in immunology - 1 Jan 2024

Sng Christopher C T, Kallor Ashwin Adrian, Simpson Benjamin S, Bedran Georges, Alfaro Javier, Litchfield Kevin

Abstract excerpt

Background: Neoantigens, mutated tumour-specific antigens, are key targets of anti-tumour immunity during checkpoint inhibitor (CPI) treatment. Their identification is fundamental to designing neoantigen-directed therapy. Non-canonical neoantigens arising from the untranslated regions (UTR) of the genome are an overlooked source of immunogenic neoantigens. Here, we describe the landscape of UTR-derived...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38558815
DOI: 10.3389/fimmu.2024.1347542
PMCID: PMC10978585

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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