Article

Glycation Stress–Driven Transcriptomic Signature Predicts Survival Benefit from Adjuvant Gemcitabine in Resectable Pancreatic Cancer

2025-07-09

Abstract excerpt

<h4>BACKGROUND & AIMS</h4> Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with limited response to systemic therapy. Gemcitabine (GEM) benefits only a subset of patients. Methylglyoxal (MG), a glycolysis byproduct, has been linked to tumor behavior and therapy response in PDAC, suggesting potential as a stratification marker. <h4>METHODS</h4> We developed a metabolically informed gene signatur...

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Literature Corpus work: 91678876-8126-58ae-9270-a49a0b807a74
DOI: 10.1101/2025.07.07.663493

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