Article

Development of a Pentacistronic Ebola Virus Minigenome and Its Application to Model Mouse-Adapted Ebola Virus

2024-12-11

Abstract excerpt

Ebola virus (EBOV) causes hemorrhagic disease in humans with high case fatality rates. EBOV requires adaptation to cause lethal disease in mice by acquiring single mutations in both the nucleoprotein (NP) and VP24 genes. The role(s) of these two mutations in pathogenesis remains unclear. In this study, we modeled mouse-adapted EBOV (MA-EBOV) using minigenomes and transcription/replication-competent virus-like part...

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Identifiers and source

Literature Corpus work: 203fc16d-15bc-52a3-a001-b41e806cde81
DOI: 10.20944/preprints202412.0940.v1

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