Article
Generation and Characterization of a Mouse-Adapted Makona Variant of Ebola Virus.
Viruses - 26 Oct 2019
Chan Mable, Leung Anders, Griffin Bryan D, Vendramelli Robert, Tailor Nikesh, Tierney Kevin, Audet Jonathan, Kobasa Darwyn
Abstract excerpt
Ebola virus (EBOV) is a zoonotic pathogen that poses a significant threat to public health, causing sporadic yet devastating outbreaks that have the potential to spread worldwide, as demonstrated during the 2013-2016 West African outbreak. Mouse models of infection are important tools for the development of therapeutics and vaccines. Exposure of immunocompetent mice to clinical isolates of EBOV is nonlethal;...
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