Generation and Characterization of a Mouse-Adapted Makona Variant of Ebola Virus.

doi:10.3390/v11110987

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Article

Generation and Characterization of a Mouse-Adapted Makona Variant of Ebola Virus.

Viruses - 26 Oct 2019

Chan Mable, Leung Anders, Griffin Bryan D, Vendramelli Robert, Tailor Nikesh, Tierney Kevin, Audet Jonathan, Kobasa Darwyn

Abstract excerpt

Ebola virus (EBOV) is a zoonotic pathogen that poses a significant threat to public health, causing sporadic yet devastating outbreaks that have the potential to spread worldwide, as demonstrated during the 2013-2016 West African outbreak. Mouse models of infection are important tools for the development of therapeutics and vaccines. Exposure of immunocompetent mice to clinical isolates of EBOV is nonlethal;...

Topics

Animals
Disease Models, Animal
Ebolavirus
Genome, Viral
Hemorrhagic Fever, Ebola
Humans
Mice
Mice, Inbred BALB C
Mutation
Viral Load
Viral Proteins

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Identifiers

PMID: 31717793
DOI: 10.3390/v11110987
PMCID: PMC6893688

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