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Article

Rational design of self-amplifying virus-like vesicles with Ebola virus glycoprotein as vaccines

31 Aug 2024

Abstract excerpt

As emerging and re-emerging pathogens, filoviruses, especially Ebola virus (EBOV), pose a great threat to public health and require sustained attention and ongoing surveillance. More vaccines and antiviral drugs are imperative to be developed and stockpiled to respond to unpredictable outbreaks. Virus-like vesicles, generated by alphavirus replicons expressing homogeneous or heterogeneous glycoproteins (GPs),...

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PMID: 39217415
DOI: 10.1016/j.ymthe.2024.08.026

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