Article

Recombinant Lloviu virus as a model to study inaccessible zoonotic viruses

2021-08-02

Abstract excerpt

Next generation sequencing has revealed the presence of many RNA viruses in animal reservoir hosts, including many closely related to known human pathogens. Despite their zoonotic potential, many of these viruses remain understudied due to not yet being cultured. While reverse genetic systems can facilitate virus rescue, this is often hindered by missing viral genome ends. A prime example is Lloviu virus (LLOV), a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3daae392-525f-5a9c-871e-7da14b847f91
DOI: 10.1101/2021.08.02.454777

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Recombinant Lloviu virus as a model to study inaccessible zoonotic virusesDOI 10.1101/2021.08.02.454777Read

Recombinant Lloviu virus as a tool to study viral replication and host responsesSemantic proximity Read

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic MinigenomesSemantic proximity Read

A Novel Life Cycle Modeling System for Ebola Virus Shows a Genome Length-Dependent Role of VP24 in Virus InfectivitySemantic proximity Read

Reverse Genetics Recovery of Lujo Virus and Role of Virus RNA Secondary Structures in Efficient Virus GrowthSemantic proximity Read

RNA Polymerase I-Driven Minigenome System for Ebola VirusesSemantic proximity Read

Developments in Negative-Strand RNA Virus Reverse GeneticsSemantic proximity Read

Production of Novel Ebola Virus-Like Particles from cDNAs: an Alternative to Ebola Virus Generation by Reverse GeneticsSemantic proximity Read

ICTV Virus Taxonomy Profile: FiloviridaeSemantic proximity Read

The Picornaviridae Family: Knowledge Gaps, Animal Models, Countermeasures, and Prototype PathogensSemantic proximity Read

Structural insights into the RNA-dependent RNA polymerase complexes from highly pathogenic Marburg and Ebola virusesSemantic proximity Read

Abortive Infection of Animal Cells: What Goes WrongSemantic proximity Read

Flavivirus reverse genetic systems, construction techniques and applications: A historical perspectiveSemantic proximity Read