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Novel Stable Ebola Virus Minigenome Replicon Reveals Remarkable Stability of the Viral Genome

7 Sept 2017

Abstract excerpt

ABSTRACT Ebola virus (EBOV) causes severe hemorrhagic fever in humans and other primates with a high case fatality rate. No approved drug or vaccine of EBOV is available, which necessitates better understanding of the virus life cycle. Studies on EBOV have been hampered because experimentations involving live virus are restricted to biosafety level 4 (BSL4) laboratories. The EBOV minigenome system has provided...

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PMID: 28878087
DOI: 10.1128/jvi.01316-17

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