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Clinical Aspects of Microsatellite Instability Testing in Colorectal Cancer

1 Jan 2018

Abstract excerpt

Microsatellite instability (MSI) is a molecular hallmark for some colorectal cancers (CRCs) in which short tandem repeats are prone to mutations along with DNA sequences. It is due to DNA-mismatch-repair system deficiency because of a germline/somatic mutation in mismatch-repair (MMR) genes. The germline mutations lead to Lynch syndrome (LS) while epigenetic gene silencing results in sporadic CRC tumors. We...

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PMID: 29531926
DOI: 10.4103/abr.abr_185_16

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