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Article

Next-Generation Sequencing in Colorectal Cancer: Real-World Molecular Profiling and Clinical Correlations.

International journal of molecular sciences - 1 Aug 2026

Cunha Afonso, Robalo Carolina, Lemos Carolina, Lamas Nuno Jorge, Dos Santos Marisa Domingues

Abstract excerpt

Next-generation sequencing (NGS) has become a cornerstone of precision oncology in colorectal cancer (CRC), although its role in routine patient stratification remains incompletely defined. This retrospective single-centre study characterised the molecular landscape of clinically selected CRC patients undergoing routine NGS and explored associations between genomic alterations and clinicopathological features. 97...

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Source

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Identifiers

PMID: 42589583
DOI: 10.3390/ijms27156930
PMCID: PMC13466781

Genes

BRAF
KRAS
PIK3CA
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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