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Article

Lynch Syndrome in Context of the Updated German S3 Guideline Colorectal Cancer: Implementation of Universal MMR/MSI Testing.

Oncology research and treatment - 1 Jan 2026

Vangala Deepak B, Seufferlein Thomas, Hüneburg Robert

Abstract excerpt

BACKGROUND: With 1:280 carriers, Lynch syndrome (LS) is the most prevalent tumor predisposition syndrome and the most important cause for hereditary colorectal cancer (CRC). Tumors from affected individuals usually present with a deficient expression of mismatch repair (MMR) proteins leading to a high microsatellite instability (MSI). SUMMARY: With the update of the German S3 guideline CRC, universal MSI/MMR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40675142
DOI: 10.1159/000547331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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