Article

A Primer on Modeling and Measurement of Signaling Outcomes Affecting Decision Making in Cells: Methods for Determining Optimal and Incorrect Outcomes in Noisy Biochemical Dynamics

2019-12-23

Abstract excerpt

Characterization of decision makings in a cell in response to received signals is of high importance for understanding how cell fate is determined. The problem becomes multi-faceted and complex when we consider cellular heterogeneity and dynamics of biochemical processes. In this paper, we present a unified set of decision-theoretic and statistical signal processing methods and metrics to model the precision of si...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 20262094-f9de-5ff6-8660-d6a3ff6bd020
DOI: 10.1101/2019.12.21.885491

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Primer on Modeling and Measurement of Signaling Outcomes Affecting Decision Making in Cells: Methods for Determining Optimal and Incorrect Outcomes in Noisy Biochemical DynamicsDOI 10.1101/2019.12.21.885491Read

Quantitative analysis of cellular perception in eukaryotic signalling networksSemantic proximity Read

Surprisal analysis of transcripts expression levels in the presence of noise: a reliable determination of the onset of a tumor phenotype.Semantic proximity Read

What's Luck Got to Do with It: Single Cells, Multiple Fates, and Biological Nondeterminism.Semantic proximity Read

Decoding stimulus-specific regulation of promoter activity of p53 target genesSemantic proximity Read

Low-frequency ERK and Akt activity dynamics are predictive of stochastic cell division eventsSemantic proximity Read

Quantifying the phenotypic information in mRNA abundance.Semantic proximity Read

Noise decomposition of intracellular biochemical signaling networks using nonequivalent reporters.Semantic proximity Read

In silico study of medical decision-making for rare diseases: heterogeneity of decision-makers in a population improves overall benefitSemantic proximity Read

Information transfer by leaky, heterogeneous, protein kinase signaling systems.Semantic proximity Read

Which is better for cDNA-microarray-based classification: ratios or direct intensities.Semantic proximity Read

A Bayesian determination of threshold for identifying differentially expressed genes in microarray experiments.Semantic proximity Read

Evaluation of information flows in the RAS-MAPK system using transfer entropy measurementsSemantic proximity Read