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Article

Quantifying the phenotypic information in mRNA abundance.

Molecular systems biology - 1 Aug 2022

Maltz Evan, Wollman Roy

Abstract excerpt

Quantifying the dependency between mRNA abundance and downstream cellular phenotypes is a fundamental open problem in biology. Advances in multimodal single-cell measurement technologies provide an opportunity to apply new computational frameworks to dissect the contribution of individual genes and gene combinations to a given phenotype. Using an information theory approach, we analyzed multimodal data of the...

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PMID: 35965452
DOI: 10.15252/msb.202211001
PMCID: PMC9376724

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