Article
Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies.
Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 2015
Townsend Sue, Fennell Brian J, Apgar James R, Lambert Matthew, McDonnell Barry, Grant Joanne, Wade Jason, Franklin Edward, Foy Niall, Ní Shúilleabháin Deirdre, Fields Conor, Darmanin-Sheehan Alfredo, King Amy, Paulsen Janet E, Hickling Timothy P, Tchistiakova Lioudmila, Cunningham Orla, Finlay William J J
Abstract excerpt
Although humanized antibodies have been highly successful in the clinic, all current humanization techniques have potential limitations, such as: reliance on rodent hosts, immunogenicity due to high non-germ-line amino acid content, v-domain destabilization, expression and formulation issues. This study presents a technology that generates stable, soluble, ultrahumanized antibodies via single-step...
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