Article

The Lipolysis-Stimulated Lipoprotein Receptor Contributes to Direct and Antibody-Enhanced SARS-CoV-2 Pathogenicity

2023-07-21

Abstract excerpt

Severe COVID-19 damages alveolar lung cells that lack the angiotensin-converting enzyme 2 (ACE2) but express the lipolysis-stimulated lipoprotein receptor (LSR). Here we show that LSR enabled SARS-CoV-2 to produce infectious progenies and cause cell death. LSR-mediated cytolysis resulted from cathepsin L cleavage of the spike protein and occurred when the viral load reached a critical threshold. Monoclonal antibod...

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Literature Corpus work: 1ffb4c86-b250-574b-a515-77936cf0f49a
DOI: 10.2139/ssrn.4512950

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