Article

Lung-selective Cas13d-based nanotherapy inhibits lethal SARS-CoV-2 infection by targeting host protease <i>Ctsl</i>

2021-10-05

Abstract excerpt

<h4>SUMMARY</h4> The COVID-19 pandemic persists as a global health crisis for which curative treatment has been elusive. Development of effective and safe anti-SARS-CoV-2 therapies remains an urgent need. SARS-CoV-2 entry into cells requires specific host proteases including TMPRSS2 and Cathepsin L (Ctsl) 1–3 , but there has been no reported success in inhibiting host proteases for treatment of SARS-CoV-2 pathog...

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Literature Corpus work: ac46e820-ac88-56f7-b55a-a30cad25a269
DOI: 10.1101/2021.10.03.462915

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