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Article

Cathepsin L in COVID-19: From Pharmacological Evidences to Genetics.

Frontiers in cellular and infection microbiology - 1 Jan 2020

Gomes Caio P, Fernandes Danilo E, Casimiro Fernanda, da Mata Gustavo F, Passos Michelle T, Varela Patricia, Mastroianni-Kirsztajn Gianna, Pesquero João Bosco

Abstract excerpt

The coronavirus disease 2019 (COVID-19) pandemics is a challenge without precedent for the modern science. Acute Respiratory Discomfort Syndrome (ARDS) is the most common immunopathological event in SARS-CoV-2, SARS-CoV, and MERS-CoV infections. Fast lung deterioration results of cytokine storm determined by a robust immunological response leading to ARDS and multiple organ failure. Here, we show cysteine...

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Identifiers

PMID: 33364201
DOI: 10.3389/fcimb.2020.589505
PMCID: PMC7753008

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