Article

Long-term multi-modal recording reveals unpredictable nongenetic adaptation routes in dormant breast cancer cells.

2022-03-24

Abstract excerpt

<title>Abstract</title> <p>Patients diagnosed with hormone dependent breast cancer (HDBC) receive five or more years of adjuvant endocrine therapies (ET). Adjuvant treatment delays relapse1,2 by targeting hidden micro-metastatic deposits, yet up to 50% of treated patients experience recurrent disease, often many years after surgery1. The mechanisms driving these subtype-specific clinical dynamics are largely unkn...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1ff0607a-49bd-59ff-83bc-bf87d239fdf4
DOI: 10.21203/rs.3.rs-1435182/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Long-term multi-modal recording reveals unpredictable nongenetic adaptation routes in dormant breast cancer cells.DOI 10.21203/rs.3.rs-1435182/v1Read

Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer CellsSemantic proximity Read

Unperturbed dormancy recording reveals stochastic awakening strategies in endocrine treated breast cancer cellsSemantic proximity Read

Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast CancerSemantic proximity Read

Decoding the adaptive survival mechanisms of breast cancer dormancySemantic proximity Read

Gene expression predicts dormant metastatic breast cancer cell phenotype.Semantic proximity Read

HES1 oscillations are required for cell cycle re-entry in oestrogen receptor positive breast cancer cellsSemantic proximity Read

Molecular changes during extended neoadjuvant letrozole treatment of breast cancer: distinguishing acquired resistance from dormant tumoursSemantic proximity Read

Single-cell transcriptomics reveals multi-step adaptations to endocrine therapySemantic proximity Read

Adaptation and selection shape clonal evolution of tumors during residual disease and recurrenceSemantic proximity Read

Genomic hallmarks of cellular dormancy in cancer and therapeutic implicationsSemantic proximity Read

Live Cell Lineage Tracing of Dormant Cancer CellsSemantic proximity Read

Dormancy, stemness, and therapy resistance: interconnected players in cancer evolutionSemantic proximity Read