Article

HES1 oscillations are required for cell cycle re-entry in oestrogen receptor positive breast cancer cells

2025-08-05

Abstract excerpt

Long-term recurrence in breast cancer is driven by reactivation of dormant disseminated tumour cells (DTCs) and remains a major clinical challenge, particularly in oestrogen receptor positive (ER⁺) tumours. This process is underpinned by regulation of the cell cycle machinery that controls quiescence maintenance and exit. HES1, a Notch pathway transcription factor, regulates key cell cycle genes and has been shown...

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Literature Corpus work: 285236ab-7d7f-5680-827a-06bf88adfca1
DOI: 10.1101/2025.08.04.668440

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